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Mechanismus vášní v „économie animale“. K otázce vášní duše v osvícenské medicíně

Mechanismus vášní v „économie animale“. K otázce vášní duše v osvícenské medicíně

Author(s): Daniela Tinková / Language(s): Czech Issue: 02/2014

The aim of this study is to show how the emotions — in particular the so-called “passions of the soul” — were understood and interpreted in the medical thinking of the late Enlightenment. We focus chiefly on three innovations in 18th century medicine: the “discovery” of the neuro-cerebral system (the ’birth’ of neurology); the search for the “seat” of illnesses in particular organs (the “birth” of pathological anatomy); and the gradual separation of the body and the soul as objects of medical enquiry (the “birth of psychiatry). We consider whether, and to what extent, these innovations contributed to the breakdown of the “old” diagnostic paradigms of the “passions of the soul”, or whether in fact they helped to maintain them. We also discuss to what extent the consideration of these passions fostered a new approach to the relationship between the body and the soul in Enlightenment medicine. Some of the phenomena studied are illustrated by specific examples of (erotic) love and melancholy.

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Stages of development requirement of the state

Stages of development requirement of the state

Author(s): Glazunov Yuri Trofimovich / Language(s): English Issue: 6/2018

The article deals with the stages of development meets the needs. Introduced the concept of a bifurcation point requirement of the state. three bifurcation points identified. Shown, thatthe transition needs to the highest level of the previous requirement of a state does not disappear. It is part of the new requirement of the state.

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Depression and its treatment - a mini review

Depression and its treatment - a mini review

Author(s): Ansari Iqra,Jabbar Qammar,Shah A. Asim / Language(s): English Issue: 6/2018

Major depressive disorder (MDD) is one of the most common mental health conditions in the United States. Depressed mood for at least two-week period could be diagnosed as MDD. A variety of pathological and neurotransmitter changes could result in the development of the MDD. Combination of non-pharmacological and pharmacological therapies could be utilized to treat the depression. The antidepressant use could result in their respective side effects. Therefore, the choice of medication needs to be tailored keeping in consideration the individual characteristics and safety profile.

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Allosteric modulators in CNS disorders: review

Allosteric modulators in CNS disorders: review

Author(s): Roy Sebastian / Language(s): English Issue: 6/2018

A variety of central nervous system disorders were treated using G protein-coupled receptors (GPCRs) modulators. The discovery of allosteric modulators of GPCRs offers novel treatments with added benefits compared to orthosteric site modulators of GPCRs. The target site for allosteric modulators is separate from the orthosteric site and is still able to modulate the receptor function. Allosteric modulators either potentiate or inhibit the receptor response, and provide much greater subtype selectivity those orthostatic agents for the same receptors. Experiments revealed Positive Allosteric Modulators show allosteric agonism when used in combination with an endogenous ligand. Allosteric modulators permit increased drug selectivity and demonstrate a significant decrease in adverse effects. Studies showed the potential of some allosteric modulators of GPCRs and AMPA receptors in multiple Central Nervous System disorders including Alzheimer’s and Parkinson’s disease.

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Concurrence anorexia and pseudo-turner syndrome

Concurrence anorexia and pseudo-turner syndrome

Author(s): John Parkinson / Language(s): English Issue: 6/2018

Objective: While more than twenty concurrences of anorexia nervosa with turner’s syndrome (45X0) have been reported, this is the second report of a concurrence with the Turner Phenotype (46,XX). Method: Patient’s history, hospital presentation and progress are described. Results: Dieting would convert a plump, baby-like figure to a normally proportioned though miniature adult. There were mood swings and paranoid episodes. Conclusions: Short stature seems a key factor when anorexia occurs in Turner’s patients.

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Ketamine: An important drug with a serious adverse effect - a review

Ketamine: An important drug with a serious adverse effect - a review

Author(s): Roy Sebastian / Language(s): English Issue: 6/2018

Depression is a devastating mental disorder with a broad spectrum ranging from mild depression to major depressive disorder. There have been many drugs in use to treat depression that acts through different mechanisms. Most of the anti-depressant drugs will take weeks or months to take effect, and the discovery of the use of ketamine for depression has been widely studied. Ketamine is a glutamate -based antidepressant acts by blocking N-Methyl D-Aspartate receptors that show rapid antidepressant actions within hours of treatment, even useful to treat suicidal ideations. Ketamine enhances mTOR signaling, and this nonconventional mechanism offers novel approaches for the treatment of depression. Ketamine is also having shown to be effective to reduce post-operative pain and inflammation. In spite of all these benefits, ketamine has some serious adverse effects. Among them, ketamine cystitis is an important one especially in young population and requires attention towards its management. Dimethyl sulfoxide is a FDA approved drug used for bladder instillation. Further studies should be done to prevent and manage ketamine cystitis.

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Psychotherapy of phantom pain in oncology

Psychotherapy of phantom pain in oncology

Author(s): Tkachenko G.,A. Stepanova / Language(s): English Issue: 6/2018

Psychotherapy using the "mirror box" (by V. Ramachandran) and progressive muscle relaxation (by E. Jacobson) in combination with music are effective in correcting phantom pain in patients with malignant tumors of bones and soft tissues. Analysis of VAS data before and after the correction showed a significant reduction in phantom pain in the patients examined: from 73.9+9.0 to 58.9±7.9 scores, respectively (Student’s t-test = 4.7; P <0.05). By Wong-Baker scale, a significant decrease in the intensity of phantom pain from 7.7±1.1 to 5.7±1.1 scores (Student’s t-test =5, P <0.05).

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Self-trust, trust/distrust to other people in volunteers

Self-trust, trust/distrust to other people in volunteers

Author(s): Aldasheva Aigul Abdulhaevn,Loginova Mariya Aleksandrovna,Runets Oksana Vladimirovna / Language(s): English Issue: 6/2018

The article considers the level of self-trust as a system forming factor of the prosocial activity of volunteers. It is shown that volunteers with a high level of self-trust are characterized by less psychological distance in the relationship of trust to others, which is based on identity, while volunteers with an average level of self-trust relate to others on knowledge. Volunteers with a low level of self-trust in prosocial behavior in the course of interaction replace their trust with other interchange taking into account their own interests.

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Obesity aging linked to over sex more to get Alzheimer’s

Obesity aging linked to over sex more to get Alzheimer’s

Author(s): Rahul Hajare / Language(s): English Issue: 6/2018

An extra fat can extra harmonised obesity and over sex worsens the effects of ageing on brain function. Corresponding angle of some natural sex restore the appearance of face. Unsymmetrical obese can lead over sex more likely to get Alzheimer’s.

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Neuropsychological alterations in borderline personality disorder: purpose of a case

Neuropsychological alterations in borderline personality disorder: purpose of a case

Author(s): TM Torres-Rincón,A. Piñon-Blanco,E. Vázquez-Justo,F. Otero-Lamas / Language(s): English Issue: 6/2018

Different investigations reveal the neurological and neuropsychological differences among patients with BPD. The objective of this case study is to describe the neuropsychological (cognitive, executive), symptomatological and personality alterations of a patient with dual pathology and the implications that these alterations have in their daily lives. A battery of neuropsychological evaluation was applied to a patient undergoing treatment at the CEDRO Vigo drug dependence unit. The results reflect a neuropsychological performance indicative of a medium premorbid intelligence, a reduced speed of psychomotor and visuospatial processing, deficits in tasks of verbal memory, an executive functioning determined by alterations in the executive components of actualization, change and inhibition. As well as difficulties in social and work activity and a symptomatological profile characterized by obsessive-compulsive, anxious and psychotic clinical manifestations, an elevated motor and unplanned impulsivity, and a tendency to yield to positive affections and reduced perseverance. Neuropsychological exploration helps us to detect deficits in the cognitive / executive processes, generates awareness of the deficit and allows realizing a neuropsychological profile, which facilitates the design and elaboration of individualized treatment programs.

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Cognitive decline and swiss cheese aspect revealing temporal radionecrosis after nasopharyngeal carcinoma radiation therapy: case report and literature review

Cognitive decline and swiss cheese aspect revealing temporal radionecrosis after nasopharyngeal carcinoma radiation therapy: case report and literature review

Author(s): Youssouf Benmoh,Youness Mamouni Alaoui,Kawtar Zaoui,Mohamed Hamid,Mohamed Zakaria Bichra,Karim Reda,Ahmed Bourazza / Language(s): English Issue: 5/2018

Background: The radiation therapy effectiveness is certain in naso-pharyngeal carcinoma (NPC) and other head and neck malignancies. In this context, cerebral radionecrosis (CRN) is a late radiotherapy related-side effect. Its incidence is above 5%, when the total dose is less than 60 grays, and the fraction size less than 2 grays. We report a rare case of late cerebral radio necrosis , its clinical manifestation, MRI specific aspect compared to its main differential diagnosis (brain metastatic tumor), and the evolution under specific treatment, with a review of reported cases over the literature. Case report: 53 years-old man, diagnosed for having nasopharyngeal carcinoma, and was treated by chemotherapy and external radiotherapy. 6 years after later, he presented progressive cognitive decline with phasic and mnesic complaints, associated to balance disorder. Clinical examination objectified dementia detected by Montreal Cognitive Assessment (MoCA) score, with normal Mini Mental State (MMS), associated to pyramidal and vestibular syndrome. Cerebral MRI showed swiss cheese and soap bubble aspect in left temporal lobe, and spectroscopy showed decreased creatinine and N-acetyl-aspartate peak. He was treated as having temporal radio necrosis by hyperbaric oxygen, corticotherapy and anti-platelets. His clinical and radiological condition improved. Conclusion: We learn that cognitive decline may be the revealing symptom of cerebral radio necrosis. In this case, MoCA test showed more sensitivity. Thus clinician must bear in mind the risk of cerebral radio necrosis (CRN) as much as metastatic or recurrent brain tumor in such situation. The MRI with specific pattern could help in distinguish these entities. Corticosteroid associated to hyperbaric oxygen and anti-platelets improve the course of CRN. The use of promoting agent anti-VEGF Bevacizumab should be clarified by more prospective studies.

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The impact of sleep in fibromyalgia, an exploratory study

The impact of sleep in fibromyalgia, an exploratory study

Author(s): Cécile Domingues,Carla Oliveira,Isabel Gomes,Joana Oliveira,Marta Calado / Language(s): English Issue: 5/2018

Fibromyalgia has been referred to as one of the most common rheumatological pathologies in the world´s population, coming in fourth place in Spain and Bangaldesh, second in the USA, Brasil and Mexico (Assumpção, 2006). Regarding the recovery cases of people who sought help at Clínica da Mente, prior to this study, with complaints regarding emotional issues and who had Fibromyalgia, this study aims to investigate to which extent the perception of quality of sleep affects the perception of pain in patients with fibromyalgia. The results point to a significant correlation between quality of sleep and perception of pain (ρ=0,994 para p≤0,01). It was also demonstrated that emotional states such as depression, anxiety and stress disturb the perception of quality of sleep. As such, emotional states condition sleep, which in turn conditions the perception of pain in patients with fibromyalgia.

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Overview: occupational therapy for psychiatric disorders

Overview: occupational therapy for psychiatric disorders

Author(s): Hassan Izzeddin Sarsak / Language(s): English Issue: 5/2018

This review article provides an overview of the role of occupational therapy (OT) in the intervention of psychiatric disorders. Furthermore, it provides evidence of occupational therapy’s contribution to mental and behavioral health. PICO method was used to develop research question and a thorough review was conducted to identify most relevant evidence-based research related to the effectiveness of OT in the intervention of psychiatric disorders and its contribution to mental health. Throughout the article evidence-based occupational therapy interventions are emphasized. Our review revealed that occupational therapy complements psychotherapy and other medical treatments and has proven to be useful and effective in managing symptom of psychiatric disorders and enhancing and/or maintaining functional performance for persons with mental health problems.

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Pharmacogenomics in the psychiatric population

Pharmacogenomics in the psychiatric population

Author(s): Olubunmi A. Omoshebi,Nicholas A. Kerna,Tony L. Brown / Language(s): English Issue: 3/2018

Recent research has revealed that patients may metabolize the same drug differently. Why and how does this occur? Investigation into the expanding field of pharmacogenomics can help answer these two questions. Pharmacogenomics is the study of all genes in the genome that may determine drug response.1 Looking into studies where psychiatric patients have been diagnosed with the same disease, it has been observed that a large sample of patients react differently to similar or the same medications. In pharmacogenomics of the psychiatric population, drugs are divided into three categories based on safety and effectiveness: red category, yellow category, and green category; red-zone, yellow-zone, and green-zone. The subjects of the studies cited herein are a sampling of those who took either red, yellow, or green categorized FDA-approved drugs. There is also a small sample of subjects who took a combination of yellow and green drugs simultaneously. However, there are no subjects that took a combination of red and yellow or a combination of red and green; and there are also no subjects that took drugs from all three categories. Drugs that treat depression are the focus of this research, as psychiatric medicines, such as antidepressants, have a large sampling of patients who have or have not done well with the various medications. Pharmacogenomic testing will help treat patients more effectively using medications that better correspond to the patient’s genetic makeup. This results in a more personalized approach to treatment with medicines.

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Determinant of treatment delay in the first episode of psychosis: a qualitative study

Determinant of treatment delay in the first episode of psychosis: a qualitative study

Author(s): Abd Alhadi Hasan / Language(s): English Issue: 3/2018

Aims: The aims of this study were to investigate patterns of requesting treatment amongst first-time user psychotic patients and to reveal the causes for delay in terms of accessing psychiatric care. Methods: Qualitative semi-structured interviews were carried out with 25 family relatives of people with schizophrenia. Thematic analysis was used to analyse the data. The thematic analysis highlighted four themes: lack of awareness about mental illness the symptoms associated, perceived stigma, the role of extended family, and financial problems. Results: The findings revealed that perceived stigma and fears about being labelled are the main barriers to requesting early psychiatric healthcare. Furthermore, the participants cited many different reasons linked to getting help, for example, lack of knowledge about mental illness and its related symptoms which lead to a delay in seeking help at the early stages of the illness, family and financial factors. It has been thus argued there is a need for mental health awareness campaigns to be conducted within communities. Conclusions: The study highlights the importance of enhancing knowledge about schizophrenia related spectrum to ensure patients seek treatment in a timelier manner.

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The Subtle Organic Brain Inventory of Neppe (SOBIN): a necessary tool in the neuropsychiatric population and a valuable one in psychiatry and psychology: clinical and forensic applications

The Subtle Organic Brain Inventory of Neppe (SOBIN): a necessary tool in the neuropsychiatric population and a valuable one in psychiatry and psychology: clinical and forensic applications

Author(s): Vernon M. Neppe,Shauna Mason / Language(s): English Issue: 3/2018

The SOBIN (Subtle Organic Brain Inventory of Neppe) is the only available clinical neuropsychiatric inventory screening for soft organic type symptoms and learning disabilities. It was developed in 2002 by Vernon Neppe at the Pacific Neuropsychiatric Institute in Seattle, where it’s used extensively. The SOBIN is a paper-and-pencil screen of pertinent medical history relating to higher brain function. It is designed to integrate six major elements: a. Primarily, the items elicit soft organic brain pathology. This is particularly important in the broad spectrum of neuropsychiatric cases ranging from possible brain injury, to psychopathology, to soft organic impairments that may have been lifelong, such as in evaluating subtle difficulties like prosopagnosia, dysproccia and attention deficits. b. Secondly, the SOBIN allows for monitoring patient-reported changes, including after significant pathology like head injury or encephalitis. c. Thirdly, the SOBIN provides awareness of the subjective cognitive areas of special strengths. d. Fourthly, the questions elicit monitoring ordinal severity fluctuations in higher brain function. This is particularly useful in medicolegal cases, as well as cases where distinct events such as traumatic brain injury occurs. e. Fifthly, the SOBIN assists with obtaining ancillary baseline data, ranging from laterality to personality to symptom triggers, additional to the INSET (Inventory of Neppe of Symptoms of Epilepsy and the Temporal Lobe). f. Sixth, we have provisionally clustered the SOBIN items into 11 broad categories, modelling it on Vernon Neppe’s BROCAS SCAN, an instrument that objectively clinically measures higher brain functions. By these means we can compare the subjective and objective results, though the items historically measure broader and sometimes different items than that of the BROCAS SCAN. The SOBIN provides a consistent and standardized method of measuring reports of higher brain symptoms. It is most often combined with another of Vernon Neppe’s screens, the INSET. Together and along with the clinical examination, these tests assist the clinician in ensuring there are no indicators of invalid responses. This way one is able to better interpret neuropsychiatric tests properly. The SOBIN has unique neuropsychiatric use and applications because it is the only instrument in its class.1−3 By scoring 88 main items plus 24 ancillary items, the SOBIN-1 compares past and present, evaluates degrees of severity, and proves critical in both clinical and forensic contexts, including patients with questionable organic or brain pathology or neurological conditions with possible psychiatric elements, previous head injury or encephalitis or tumor or other brain insult or possible seizure disorders or paroxsymal neurobehavioral disorders. Further items were recently added, making up an extra 112 questions and called the SOBIN-2. The SOBIN is the name for the 200-item combination of the SOBIN-1 and the SOBIN-2. Effectively the two SOBINs (1 and 2) are now used together as a single instrument, the SOBIN. The SOBIN is the main focus here. However, because it has always been used with the INSET and with an objective evaluation of higher brain function, the BROCAS SCAN, and the 10 higher brain categories of the ROCAS applied to cluster analysis of symptoms, the INSET and BROCAS SCAN (along with the MOCA and MMSE) are included in some detail. We also apply two neglected conditions—prosopagnosia and dysproccia—as examples of how to apply clinical data and ultimately research using the SOBIN.

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The Moderating Role of Neuroleadership on the Effect of Emotional Intelligence and Transformational Leadership on Employee Performance at Mutiara Sukma Psychiatric Hospital, West Nusa Tenggara, Indonesia

The Moderating Role of Neuroleadership on the Effect of Emotional Intelligence and Transformational Leadership on Employee Performance at Mutiara Sukma Psychiatric Hospital, West Nusa Tenggara, Indonesia

Author(s): Ajeng Retno Wulandari,Hermanto Hermanto,Dwi Putra Buana Sakti / Language(s): English Issue: 6/2024

This study examines the moderating role of neuroleadership on the effect of emotional intelligence and transformational leadership on employee performance. This type of research is a causal associative research with a quantitative approach. The researchers used the quota sampling technique to select 112 respondents from the total population of 448 employees at the Mutiara Sukma Psychiatric Hospital in West Nusa Tenggara. Data analysis used the PLS-SEM technique with Smart PLS 4 software. The results showed that: 1) Emotional intelligence had a significant positive effect on employee performance; 2) transformational leadership had a significant positive effect on employee performance; 3) Neuroleadership can strengthen the effect of emotional intelligence on employee performance; 4) Neuroleadership strengthens the effect of transformational leadership on employee performance. The results of this study can be a reference and consideration for companies in applying applied neuroscience in the context of effective leadership for organisations.

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Therapeutic Strategies in the Cognitive Impairment of Schizophrenia
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Therapeutic Strategies in the Cognitive Impairment of Schizophrenia

Author(s): Doina Cosman,Horia Coman / Language(s): English Issue: 1/2024

We will first have an historical survey of cognitive impairment in schizophrenia, with special reference to Emil Kraepelin and Eugen Bleuler. We will then consider the types of cognitive schizophrenia-wise deficits, the assessment of cognitive impairment, the clinical significance of cognitive impairment, the neurocognitive predictors of functionality, psychopharmacology and cognitive function. We will finally state that partial compliance is the main cause of high dropout rates.

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Заучена безпомощност като модел на депресия

Заучена безпомощност като модел на депресия

Author(s): Nelly Koleva / Language(s): Bulgarian Issue: 1/2023

Our goal in this article is to present the learned helplessness as a model of depression that could shed some light on the causes and prevention of this disorder. At the beginning of this century, all depressions were mistakenly defined as manic-depressive disorders, but it is now known that sometimes depression occurs without mania and vice versa mania can occur without depression. Six symptoms of learned helplessness are evident from psychological research, and each symptom has a parallel in depression. A number of features of depression have so far been insufficiently studied only in the case of learned helplessness.

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An Unknown Case of Speech Encryption

An Unknown Case of Speech Encryption

Author(s): Dan Howitt / Language(s): English Issue: 20/2023

Profoundly autistic man Tito Mukhopadhyay has been presented as the perfection of the perfection of autism treatment. A cure for autism has of course never been devised. And no one even knows what kind of treatment could even possibly cure autism, because no one knows what the neurological mechanism of autism is. However, I demonstrate that Tito’s communication therapist engaged in multifaceted communicative deception with him during the 2003 – 2017 extensive nationally televised presentations of the therapists’ communicative method. The therapist is Soma Mukhopadhyay, who also is Tito’s mother. It was not known that she was using a speech encryption method, nor other methods of deception. However, from the outset there was suspicion among a vast array of scientists, clinicians, etc., that she was, somehow, responsible for Tito’s written communications. However, despite that they analyzed Soma’s presentations with Tito, and published journal-articles on the “absence of evidence” that Tito, himself, was communicating, they were not able to auditorily observe the speech encryption, nor visually observe and auditorily observe the other methods of deception. That is, they were not able to observe “proof of deception”. “Absence of evidence” and “proof of deception” are of course different. In 2008, a team of scientists who studied Soma and Tito for over 1 year, including the renowned Michael Merzenich, and in 2011 the renowned Oliver Sacks, concluded that there is an abundance of evidence that Tito himself is able to communicate via writing. However, I demonstrate that there is an abundance of proof of deception, and that Sacks, Merzenich, etc., were not able to observe the speech encryption and other methods of deception. (This article consists of revisions and a correction of my 2021 article).

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