SUPPORTING CONCEPTUAL LEARNING IN ORGANIC CHEMISTRY THROUGH SEMI-EMPIRICAL MOLECULAR MODELING: HEURISTICS OF DIELS-ALDER [4+2] CYCLOADITIONS FOR PREPARATION OF POTENTIAL TLR4 MODULATORS
SUPPORTING CONCEPTUAL LEARNING IN ORGANIC CHEMISTRY THROUGH SEMI-EMPIRICAL MOLECULAR MODELING: HEURISTICS OF DIELS-ALDER [4+2] CYCLOADITIONS FOR PREPARATION OF POTENTIAL TLR4 MODULATORS

Author(s): Rafael Doležal, Natálie Karásková, Nadezhda V. Maltsevskaya, Karel Kolář
Subject(s): Education, School education
Published by: Scientia Socialis, UAB
Keywords: conceptual learning; diels-alder cycloadditions; molecular modeling; RM1; activation energy;
Summary/Abstract: A vast majority of novices in universities predominantly utilize algorithmic mental processes to resolve assigned tasks and tests. Although algorithmic thinking is an essential part of human cognitive functions, experts on didactics call for methods, which develop also conceptual thinking in beginners. Currently, heuristic molecular modeling gains an important position in chemistry education since it inherently integrates several conceptual thinking principles. Herein, it is focused on computational analysis of eight potential immunomodulators prepared by Diels-Alder reactions to exemplify conceptualized chemistry learning.

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