Conservation of the Upstream Open Reading Frames in the Genes for the ERB-B2 Receptor Tyrosine Kinase 2 in Vertebrates
Conservation of the Upstream Open Reading Frames in the Genes for the ERB-B2 Receptor Tyrosine Kinase 2 in Vertebrates

Summary/Abstract: In humans a short open reading frame (ORF) precedes the sequence of the erb-b2 receptor tyrosine kinase 2 (erb-b2). It is established that the upstream ORF plays an important role in erb-b2 gene expression. In this report we show that an upstream ORF is present in all vertebrate genes coding for erb-b2 receptor tyrosine kinase 2. The position and the structure of erb-b2 upstream ORF is compared between six different vertebrates. Amphibians and all land vertebrates share the same uORF characteristics. In bony fishes, however, the upstream ORF is noticeably different. This suggests that the regulation of erb-b2 gene by uORF originated in its present form with the amphibians

• Details
• Contents