Cardiac Consequences of Myocardial Infarction: An Analytical Overview of Complications in Recent Clinical Research
Cardiac Consequences of Myocardial Infarction: An Analytical Overview of Complications in Recent Clinical Research

Summary/Abstract: Acute myocardial infarction (MI) remains a major cause of morbidity and mortality globally. Despite advances in reperfusion and secondary prevention, MI survivors face long-term complications such as heart failure (HF), arrhythmias, mechanical issues, and adverse cardiac remodeling. This review synthesizes recent clinical findings (2015–2025) on post-MI complications, focusing on HF, arrhythmias, mechanical complications, and ventricular remodeling, and highlights clinical implications and research gaps. We conducted a focused review of 15 major studies, including large randomized trials, registry analyses, and observational studies, Chronic HF remains a common long-term outcome despite neurohormonal therapies like ARNI and SGLT2 inhibitors, which modestly reduce HF hospitalizations but show no significant impact on mortality. Life-threatening arrhythmias have decreased with modern reperfusion, but early ventricular arrhythmias increase in-hospital death risk by more than 3.8-fold. Mechanical complications, such as ventricular septal defects and papillary muscle rupture, are rare (and obesity. Therapies like ARNI and SGLT2 inhibitors slow remodeling but do not fully prevent HF. Post-MI complications, particularly HF, remain a significant challenge despite advances in care. Further research is needed to develop more effective therapies and personalized care strategies to improve outcomes for MI survivors.

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