Prenatal Enflamasyon ve Dikkat Eksikliği Hiperaktivite Bozukluğu İlişkisi
Relationship between Prenatal Inflammation and Attention Deficit Hyperactivity Disorder

Summary/Abstract: Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder characterized by attention deficit, hyperactivity, and impulsivity. ADHD presents impairments in academic, social, emotional and cognitive domains. Genetic and environmental factors play a role in the etiology of ADHD. Numerous studies showed that parameters associated with inflammation were higher in patients with ADHD. Due to the co-occurrence of ADHD and allergic and immunologic disorders, it is thought that the immune system has an effect on ADHD etiology. Previous studies showed that there is a strong association between prenatal inflammation exposure and neurodevelopmental disorders. Maternal diabetes mellitus, body mass index, preeclampsia, infections and chronic or autoimmune disorders of the mother are accepted as prenatal risk factors of ADHD. All these risk factors are associated with the immune profile of the mother. Because of this, the association between ADHD and intrauterine inflammation exposure is attractive. In this paper, the association of ADHD and perinatal inflammation due to maternal immune activation is reviewed.

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