The process of microRNAs discovery Cover Image

The process of microRNAs discovery
The process of microRNAs discovery

Author(s): Paweł Kawalec
Subject(s): Philosophy, Special Branches of Philosophy, Philosophy of Science
Published by: Copernicus Center Press
Keywords: breakthrough research;let-7;lin-4;particularism;processualism;scientific discovery;research routine;microRNAs;noncoding RNA

Summary/Abstract: The widespread particularist account of the onset of molecular biology that identifies it with the discovery of the DNA structure in 1953 has been recently contested. The paper contributes to this debate by focusing on a more recent discovery of small noncoding RNAs (microRNAs). First, it outlines a particularist account of the microRNAs discovery and the origins of the particularist predilection of the modern scientometric studies of science dynamics. Next, it discusses its limitations and proposes an alternative, modified processualist account of the discovery. In the final part, the paper applies this approach to unravel network dynamics of the research on the first two microRNAs that were discovered, namely lin-4 and let-7.

  • Issue Year: 2020
  • Issue No: 68
  • Page Range: 219-242
  • Page Count: 24
  • Language: English