Contribution of genetic background in HIV elite controllers
Contribution of genetic background in HIV elite controllers

Summary/Abstract: Translational medical research is a rapidly developing field, bridging fundamental and clinical science. Implementation of this domain has become increasingly prominent during the past decades, leading to a better understanding of HIV infection, where molecular genetics and bioinformatic tools have been integrated into the clinical field. It has also significantly impacted the way HIV treatment is conducted, particularly in terms of preventing the hypersensitivity reaction to abacavir through the study of the HLA-B*57:01 allele. Moreover, new cohorts of long-term non-progressors have been identified and described, namely the elite controllers (ECs) and viremic controllers (VCs). Studies have revealed a potential protective mechanism allowing the suppression of HIV replication in the absence of ART, as being related to the presence of rare HLA alleles in their genome.

• Details
• Contents