Składniki spliceosomu jako cel terapii przeciwnowotworowych
Components of spliceosomes as a target of anti-cancer therapy

Summary/Abstract: Splicing is catalyzed by the spliceosome, which is a large RNA-protein complex composed of five small nuclear ribonucleoproteins (snRNP). Spliceosome assembly is a highly dynamic process in which a number of factors is involved. Splicing reactions may play an vital role in cancerogenesis. Recently, two chemically different microbial natural products with cancer cell inhibiting potential were found to target the spliceosome. Both compounds, the pladienolide derivatives and spliceostatin A appear to bind to SF3b, a subcomplex of U2 snRNP, which is an essential part of spliceosome. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.

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