The Role of Intermittent Fasting and Calorie Restriction in Preventing Neurodegenerative Diseases within the Context of Adult Neurogenesis
The Role of Intermittent Fasting and Calorie Restriction in Preventing Neurodegenerative Diseases within the Context of Adult Neurogenesis

Summary/Abstract: Aging is considered the most important risk factor for neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases. Moreover, it is interpreted that irregular neurogenesis may also be one of the causes of neurodegenerative diseases. The brain-derived neurotrophic factor signal, a growth factor known to play an important role in the development and plasticity of the brain by promoting neurogenesis, synaptic plasticity and cell survival, decreases in the brain with aging and may be the cause of neurodegenerative diseases. Intermittent fasting or calorie restriction, a nutritional method, increases brain-derived neurotrophic factor expression in various regions of the human and rodent brain. This brings to mind the question of whether nutritional methods such as intermittent fasting and calorie restriction may play a role in preventing neurodegenerative diseases. Based on this, it has been investigated how these nutritional methods trigger adult hippocampal neurogenesis by signaling brain-derived neurotrophic factor and how they affect the brain's resistance to aging by causing changes in the hippocampus area of the brain that controls learning, memory and mood. Significant evidence obtained from human and animal studies reveals that brain-derived neurotrophic factor signaling plays a role in the beneficial effects of intermittent fasting and calorie restriction on brain aging and that this is important in terms of promising a functional result in preventing neurodegenerative diseases.

• Details
• Contents