Cytotoxicity of selected antiseptics and the safety of wound treatment
Cytotoxicity of selected antiseptics and the safety of wound treatment

Summary/Abstract: Although antiseptics are commonly used in wound treatment asantimicrobial agents, their effects on human cells remains debat-able. Despite their well-documented bactericidal efficacy, manyantiseptics can cause adverse reactions including cytotoxicity to-wards fibroblasts and keratinocytes, which can negatively affectthe wound healing process. The purpose of this paper is to evaluatethe available data on the cytotoxicity of selected antiseptics usedin wound treatment. Based on the data available in medical litera-ture, it has been demonstrated that octenidine has a relatively highBiocompatibility Index (BI), which makes it safer to use, especiallyin chronic wounds. In contrast, preparations containing chlorhex-idine, iodine, hydrogen peroxide, triclosan, or silver compoundsmay exhibit pronounced cytotoxicity, which may limit their use.

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