The prebiotic of dried powder tomato pomace and its impact on experimental atherogenesis and cancerogenesis
The prebiotic of dried powder tomato pomace and its impact on experimental atherogenesis and cancerogenesis

Summary/Abstract: Objective: The effect of dietary cellulose (5 or 15 %) and dried powder tomato pomace (15 %) on the development of atherogenesis and colon carcinoma was studied in male Wistar rats. Methods: The animals were fed with diet containing 0,3 % cholesterol and recieved 12 doses od dimetylhydrazine (20 mg.kg 1) subcutaneously in one week intervals. Fiber content in tomato peels was 47,2 g/100 g of dry mater, 10,3 % of which was inwater soluble form. Immediately after killing the animals, the colon was removed, opened longitudinally, flushed with saline, and the presence of tumors and lymphoid aggregates was assessed macro and microscopically. Results and Conclusions: Tomato pomace in the diet caused a reduction of liver content conjugated dienes by 40 % and activities of superoxide dismutase and glutatione peroxidase in liver increased two fold. Similary caused a significant reduction of average occurence of pre neoplastic lesions and incidence of dominant type of tumors as well as the total volume of tumors.

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