Протичане на COVID-19 инфекция при хоспитализирани пациенти със захарен диабет – собствен опит
Course of COVID-19 infection in hospitalized patients with diabetes mellitus - own experience

Summary/Abstract: Introduction: Infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is more severe in patients with diabetes mellitus (DM), especially in cases of type 2 diabetes (DMT2) - due to their older age, the high frequency of meta- bolic syndrome and related cardiovascular diseases (arterial hypertension, heart failure, ischemic heart disease), as well as due to the presence of micro- and macrovascular complications. Objective: To investigate the relationship between COVID-19 infection and its severity in patients with diabetes mellitus. Materials and methods: One-center retrospective study covering patients hospitalized in UMHAT Burgas AD, Burgas with a positive PCR test for SARS-CoV-2 infection, hospitalized from January 1 to January 31, 2021. Results: The analysis included 368 patients with a mean age of 55 years, 62.3% of whom were male. During hospitalization, 73 patients died (19.8%). The most common concomitant diseases are diabetes mellitus (68.3%), obesity (42.6%) and hy- pertension (42.2%). Patients with diabetes mellitus had significantly higher mortality than those without diabetes mellitus, 22.3% and 14.1%, respectively (p = 0.04). Predictors of more severe course of SARS-CoV-2 infection in addition to gender, age and concomitant diseases are smoking, the presence of bilateral infiltrates, impaired renal function and accidental plas- ma glucose above 11.1 mmol / l. Conclusion: The more severe course of SARS-CoV-2 infection in the diabetic population is probably due to older age, so- cio-economic factors, concomitant diseases, disorders of cell-mediated immunity. Patients with diabetes have an increased risk of death from any cause.

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